The Goat Polyclonal to Human EPM2A / Laforin Antibody from MyBioSource.com is a Goat Polyclonal antibody to EPM2A, and EPM2A glucan phosphatase, laforin. This antibody recognizes Human, Mouse, Rat, Bovine, Canine, Non-Human Primate, Porcine, Rabbit, and Other Mammalian antigen. The Goat Polyclonal to Human EPM2A / Laforin Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Lafora's disease, an autosomal recessive progressive myoclonus epilepsy, is caused by mutations in exons 1 and 4 of EPM2A gene. EPM2A encodes laforin which is a dual-specificity protein phosphatase located at the plasma membrane and the endoplasmic reticulum and is associated primarily with polyribosomes. EPM2A is functionally conserved in mammals and is involved in growth and maturation of neural networks